Allison DuBois (Patricia Arquette) is a strong-willed mother of three, a devoted wife who begins to suspect that she can talk to dead people, see the future in her dreams, and read people's thoughts. Fearing for her mental health, she turns to her husband Joe (Jake Weber), an aerospace engineer, for support. Joe slowly comes to believe that what his wife is telling him just might be true. The real challenge is convincing her boss, D.A. Manuel Devalos (Miguel Sandoval) -- and the other doubters in the criminal justice system -- that her psychic abilities can give them the upper hand when it comes to solving violent and horrific crimes whose mysteries often reside with those who live beyond the grave. Sofia Vassilieva and Maria Lark also star as Ariel and Bridgette, the eldest two DuBois children. David Cubitt stars as Detective Lee Scanlon, who Allison often works with on cases. As Allison and Joe's daughters continue to grow, their psychic abilities show more and more development, keeping the DuBois' home life busy and interesting. Through it all, Joe and Allison continue to balance their hectic home life with their professional lives -- which seem to become more and more stressful as time goes on.