Approximately twelve years ago, on a sunny day, in the loveliest of suburbs, in a town called Fairview, housewife Mary Alice Young (Brenda Strong) decided to end it all. Now she takes us into the lives of her friends, family and neighbors, introducing us to their relationships, their problems, and their secrets... Her circle of girlfriends on Wisteria Lane includes Susan Delfino (Teri Hatcher), a known klutz who recently moved away from her home due to financial situations; Lynette Scavo (Felicity Huffman), who has just given birth to a fifth child; Bree Van de Kamp (Marcia Cross), whose complicated life erupted once she lost her catering company to blackmail and her husband walked out on her; the ex-model turned housewife Gabrielle Solis (Eva Longoria), who finds herself chasing after two daughters and now dealing with a huge secret she's been told. The ladies now welcome their new neighbor, Renee Perry (Vanessa Williams), a former college roommate of Lynette's, who is sure to shake things up on the street. Then there are the men: Mike Delfino (James Denton), Susan's husband, a charming plumber; Lynette's adorable husband, Tom (Doug Savant), who always stays by his wife's side despite many challenges; Gabrielle's husband, Carlos (Ricardo Antonio Chavira), who works hard to provide for his wife and daughters; and Paul Young (Mark Moses), a so-called "baddie" who has returned to the lane (after a while in prison) with plans for vengeance up his sleeve. And finally there are the gay couple, Bob (Tuc Watkins) and Lee (Kevin Rahm), who moved from the city for a quieter, more peaceful life, and local busybody Karen McCluskey (Kathryn Joosten).