About nine years ago on a sunny day in the loveliest of suburbs, in a town called Fairview, housewife Mary Alice Young (Brenda Strong) decided to end it all. Now she takes us into the lives of her friends, family and neighbors... Her circle of girlfriends on Wisteria Lane includes Bree Hodge (Marcia Cross), the owner of a thriving catering business and on the verge of publishing her first cookbook; Lynette Scavo (Felicity Huffman), who struggles with raising troublesome teenaged boys who have an affinity for breaking the law; Susan Mayer (Teri Hatcher), a single mom who is on a never-ending quest for love; the ex-model turned housewife Gabrielle Solis (Eva Longoria Parker), who finds herself chasing after two daughters and looking drastically different from the model she once was. The ladies have welcomed the now single Katherine Mayfair (Dana Delany), who lived on the street once before when Mary Alice was alive, into their small, tight-knit group. However, their disdain for their prodigal neighbor, Edie Britt (Nicollette Sheridan), remains. Then there are the men: Mike Delfino (James Denton), the father of Susan's son; Lynette's adorable husband, Tom (Doug Savant), who always stays by his wife's side despite many challenges; Gabrielle's husband, Carlos (Ricardo Antonio Chavira) who was left blind in the storm that ravaged Wisteria Lane; Mary Alice's widowed husband Paul (Mark Moses), who is currently in prison for the murder of his neighbor; and Orson Hodge (Kyle MacLachlan), a devoted husband to Bree.